PF 6260933
PF-6260933
CAS: 1811510-56-1
Molecular Formula: C16H13ClN4
PF 6260933 - Names and Identifiers
| Name | PF-6260933 |
| Synonyms | PF6260933 PF-6260933 PF06260933 PF 6260933 PF 06260933 1811510-56-1 [3,3'-Bipyridine]-6,6'-diamine, 5-(4-chlorophenyl)- |
| CAS | 1811510-56-1 |
PF 6260933 - Physico-chemical Properties
| Molecular Formula | C16H13ClN4 |
| Molar Mass | 296.75 |
| Density | 1.330±0.06 g/cm3(Predicted) |
| Boling Point | 483.8±40.0 °C(Predicted) |
| Solubility | DMSO : 30 mg/mL (101.10 mM; Need ultrasonic and warming) |
| pKa | 5.04±0.13(Predicted) |
| Storage Condition | -20°C |
| Use | PF-06260933 is an orally active, highly selective MAP4K4 small molecule inhibitor with IC50 values of 3.7 and 160 nM in kinase and cell experiments, respectively. |
| In vitro study | PF-06260933 treatment of human aortic endothelial cell (EC) robustly prevents TNF-α-mediated endothelial permeability in vitro , similar to MAP4K4 knockdown. |
| In vivo study | In the mice model, PF-06260933 treatment does not alter plasma lipid content, although reductions in glucose levels are observed, which is consistent with whole-body-inducible Map4k4 knockout animals. PF-06260933 administration ameliorates further plaque development and/or promotes plaque regression in this animal model (46.0% versus 25.5%), and a reduction in plasma glucose as well as lipid content is also observed. |
PF 6260933 - Reference
| Reference Show more | 1: Roth Flach RJ, Skoura A, Matevossian A, Danai LV, Zheng W, Cortes C, Bhattacharya SK, Aouadi M, Hagan N, Yawe JC, Vangala P, Menendez LG, Cooper MP, Fitzgibbons TP, Buckbinder L, Czech MP. Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis. Nat Commun. 2015 Dec 21;6:8995. doi: 10.1038/ncomms9995. PubMed PMID: 26688060; PubMed Central PMCID: PMC4703891. 2: Ammirati M, Bagley SW, Bhattacharya SK, Buckbinder L, Carlo AA, Conrad R, Cortes C, Dow RL, Dowling MS, El-Kattan A, Ford K, Guimarães CR, Hepworth D, Jiao W, LaPerle J, Liu S, Londregan A, Loria PM, Mathiowetz AM, Munchhof M, Orr ST, Petersen DN, Price DA, Skoura A, Smith AC, Wang J. Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment. ACS Med Chem Lett. 2015 Oct 6;6(11):1128-33. doi: 10.1021/acsmedchemlett.5b00215. eCollection 2015 Nov 12. PubMed PMID: 26617966; PubMed Central PMCID: PMC4645242. |
PF 6260933 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.37 ml | 16.849 ml | 33.698 ml |
| 5 mM | 0.674 ml | 3.37 ml | 6.74 ml |
| 10 mM | 0.337 ml | 1.685 ml | 3.37 ml |
| 5 mM | 0.067 ml | 0.337 ml | 0.674 ml |
Last Update：2024-01-02 23:10:35
PF 6260933 - Introduction
PF-6260933 is an organic compound with the chemical name 2,3,5,6-tetrafluoro-4-(2,4,6-trifluorophenyl)phenol. The following is a description of its nature, use, preparation and safety information:
Nature:
1. Appearance: White to light yellow crystalline solid.
2. Melting Point: about 121-123 degrees Celsius.
3. Solubility: soluble in organic solvents, such as chlorinated alkanes, ketones, ethers, etc.; Slightly soluble in water.
Use:
1. Flame retardant: PF-6260933 is widely used in electronic products, plastics, rubber, coatings and other fields. It has good flame retardant properties and can improve the flame retardant grade of materials.
2. Optical materials: due to the transparency and high melting point of the PF-6260933, it can be used in the manufacture of optical lenses, transparent plastics and other products.
Preparation Method:
The preparation of PF-6260933 is generally carried out by chemical synthesis methods, and the specific steps may vary by manufacturer and process. A common preparation method involves reacting 2,3,5,6-tetrafluorophenol with 2,4, 6-trifluorophenylcyclopropane.
Safety Information:
1. PF-6260933 has certain toxicity, may cause irritation and injury to eyes, skin and respiratory system after contact.
2. Use should wear protective glasses, gloves and other personal protective equipment, avoid direct contact with the skin and eyes.
3. Should be operated in a well-ventilated place, and avoid inhalation of dust or vapor.
4. If swallowed or in contact with eyes or skin, rinse immediately with plenty of water and seek medical help.
5. In the use, storage and handling process, be sure to follow the safety procedures, avoid mixing with other chemicals.
Please note that the above information is only general, and the specific situation needs to be evaluated according to the actual situation and the specific information provided by the manufacturer. Consult a professional chemist or safety expert before using this compound.
Nature:
1. Appearance: White to light yellow crystalline solid.
2. Melting Point: about 121-123 degrees Celsius.
3. Solubility: soluble in organic solvents, such as chlorinated alkanes, ketones, ethers, etc.; Slightly soluble in water.
Use:
1. Flame retardant: PF-6260933 is widely used in electronic products, plastics, rubber, coatings and other fields. It has good flame retardant properties and can improve the flame retardant grade of materials.
2. Optical materials: due to the transparency and high melting point of the PF-6260933, it can be used in the manufacture of optical lenses, transparent plastics and other products.
Preparation Method:
The preparation of PF-6260933 is generally carried out by chemical synthesis methods, and the specific steps may vary by manufacturer and process. A common preparation method involves reacting 2,3,5,6-tetrafluorophenol with 2,4, 6-trifluorophenylcyclopropane.
Safety Information:
1. PF-6260933 has certain toxicity, may cause irritation and injury to eyes, skin and respiratory system after contact.
2. Use should wear protective glasses, gloves and other personal protective equipment, avoid direct contact with the skin and eyes.
3. Should be operated in a well-ventilated place, and avoid inhalation of dust or vapor.
4. If swallowed or in contact with eyes or skin, rinse immediately with plenty of water and seek medical help.
5. In the use, storage and handling process, be sure to follow the safety procedures, avoid mixing with other chemicals.
Please note that the above information is only general, and the specific situation needs to be evaluated according to the actual situation and the specific information provided by the manufacturer. Consult a professional chemist or safety expert before using this compound.
Last Update：2024-04-09 19:05:02
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Spot supply
Product Name: PF-6260933 Visit Supplier Webpage Request for quotationCAS: 1811510-56-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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